Saturday, September 26, 2020
Home Corona Mortality is reduced in Covid-19 Patients receiving Anti-coagulants

Mortality is reduced in Covid-19 Patients receiving Anti-coagulants

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The patients suffering from severe complications of Covid-19 and are treated with anticoagulants are half as likely to die than those not receiving these drugs, according to research led by cardiologist Valentin Fuster in the network of teaching hospitals Mount Sinai New York.

As a result of this research, New York hospitals have changed the way of treating the disease and are now administering anticoagulants to all patients admitted for Covid-19 except in cases where these drugs are contraindicated.

Research led by Valentín Fuster opens the way to improve treatment.

“I’ve never seen anything like what this virus does,” Dr. Fuster, who heads the Mount Sinai Cardiovascular Institute in the US, said in a telephone interview.

Many severe cases have a major problem with excess clotting.” This coagulation disorder explains the myocardial infarctions, pulmonary embolisms, and strokes that occur in Covid-19 patients, which led Fuster to think that anticoagulants could improve the treatment of the disease.

Know the enemy

“I’ve never seen anything like what this virus does,” says the cardiologist.

“Antiviral drugs such as remdesivir are very important to act against the virus, but they are not enough to treat severe manifestations of the infection, which are what can cause the death of patients,” says the cardiologist, who has organized the investigation working from his Manhattan home.

To test whether anticoagulants can be useful, doctors at Mount Sinai have analyzed data from 2,773 patients admitted by Covid-19 until April 11 in the first phase of the project. At that time, they still did not administer anticoagulants to all cases of the disease, which has made it possible to compare those who received the treatment and those who did not.

According to the results presented yesterday in the journal JACC, among the patients connected to ventilators who did not receive anticoagulants, the mortality was 63%. Among those who did receive this type of drug, it fell to 29%, less than half. The percentages were similar for different anticoagulants, both injected and taken by mouth.

Among the deceased, the meantime in the hospital before death was 9 days without anticoagulants and 21 days with treatment. These twelve days of additional survival, although they may be of little relevance to patients, confirm that the treatment is effective.

US Hospitals have changed the way of treating patients because of these results.

“One of the issues we were most concerned about was that blood thinners could increase the risk of bleeding,” explains Dr. Fuster. But only 3% of patients who received these drugs had hemorrhages, compared to 1.9% of those who did not receive them. “This result gave us the confidence to extend the treatment to more patients.”

As, this is a retrospective study, based on data from patients who received the anticoagulants based on the situation in which each one was, the results do not demonstrate that the treatment is the cause of the reduction in mortality.

The Mount Sinai team is conducting another retrospective study using data from 5,000 patients treated in the past four weeks to validate the data obtained so far. And it plans to start two clinical trials in the coming weeks, these are prospective, to determine which is the best anticoagulant and at what dose for patients admitted to the hospital and for those requiring intensive care. A third clinical trial will test whether anticoagulants can be helpful for people with Covid-19 who are not admitted to the hospital.

At the same time, the Mount Sinai team is investigating with molecular biology techniques how coagulation disorder originates and progresses in patients with Covid-19.

All the data that we are accumulating suggests that coagulation plays a central role in the serious forms of this disease,” says Valentín Fuster.

Although this line of research is in its infancy, “we have decided to publish the data as soon as possible because we are experiencing an exceptional emergency and these results may have important implications for improving the treatment of patients.” explains the cardiologist Fuster.

According to Johns Hopkins University, Worldwide Stats; LIVE DASHBOARD.

DAILY UPDATES ON GLOBAL CORONA-VIRUS PANDEMIC

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Total Cases

32,820,447

Total Deaths

994,483

Total Recovered

24,208,886

Country/Region
Confirmed cases
Deaths
Recovered
Active cases
USA
7,245,925
208,483
4,481,029
2,556,413
India
5,908,748
93,440
4,849,584
965,724
Brazil
4,692,579
140,709
4,040,949
510,921
Russia
1,143,571
20,225
940,150
183,196
Colombia
798,317
25,103
687,477
85,737
Peru
794,584
32,037
650,948
111,599
Spain
735,198
31,232
0
703,966
Mexico
720,858
75,844
518,204
126,810
Argentina
691,235
15,208
546,924
129,103
South Africa
668,529
16,312
599,149
53,068
France
513,034
31,661
94,891
386,482
Chile
453,868
12,527
428,580
12,761
Iran
443,086
25,394
372,051
45,641
UK
423,236
41,936
0
381,300
Bangladesh
357,873
5,129
268,777
83,967
Iraq
345,969
8,935
276,918
60,116
Saudi Arabia
332,790
4,655
316,405
11,730
Turkey
311,455
7,858
273,282
30,315
Pakistan
309,581
6,451
295,333
7,797
Italy
306,235
35,801
222,716
47,718
Philippines
301,256
5,284
232,906
63,066
Germany
283,706
9,530
249,500
24,676
Indonesia
271,339
10,308
199,403
61,628
Israel
217,899
1,412
153,574
62,913
Ukraine
195,504
3,903
85,133
106,468
Canada
150,456
9,255
129,573
11,628
Bolivia
133,222
7,800
92,868
32,554
Ecuador
132,475
11,236
102,852
18,387
Qatar
124,850
214
121,738
2,898
Romania
121,235
4,687
97,554
18,994
Morocco
112,522
1,998
91,932
18,592
Belgium
110,976
9,969
19,184
81,823
Dominican Republic
110,597
2,087
84,610
23,900
Panama
109,431
2,311
86,158
20,962
Netherlands
108,631
6,366
0
102,265
Kazakhstan
107,659
1,699
102,530
3,430
Kuwait
103,199
597
94,211
8,391
Egypt
102,625
5,853
93,531
3,241
Oman
95,907
885
86,765
8,257
Sweden
90,923
5,880
0
85,043
UAE
90,618
411
79,676
10,531
Guatemala
88,878
3,186
77,750
7,942
Poland
85,980
2,424
67,326
16,230
China
85,337
4,634
80,536
167
Japan
80,497
1,532
73,490
5,475
Belarus
77,289
813
74,046
2,430
Honduras
73,840
2,271
25,728
45,841
Ethiopia
72,173
1,155
29,863
41,155
Portugal
72,055
1,936
47,003
23,116
Venezuela
71,273
591
60,709
9,973
Costa Rica
70,816
812
27,023
42,981
Nepal
70,614
459
51,866
18,289
Bahrain
68,190
236
61,475
6,479
Czechia
61,318
581
30,740
29,997
Nigeria
58,062
1,103
49,606
7,353
Singapore
57,685
27
57,341
317
Uzbekistan
54,462
450
50,954
3,058
Switzerland
51,864
2,064
42,600
7,200
Algeria
50,754
1,707
35,654
13,393
Moldova
49,666
1,264
37,023
11,379
Armenia
49,072
948
43,576
4,548
Ghana
46,222
299
45,417
506
Kyrgyzstan
46,090
1,063
42,302
2,725
Austria
42,214
787
33,154
8,273
Azerbaijan
39,895
585
37,523
1,787
Afghanistan
39,192
1,453
32,635
5,104
Palestine
38,253
285
27,704
10,264
Kenya
37,707
682
24,504
12,521
Paraguay
37,226
761
21,117
15,348
Ireland
34,315
1,797
23,364
9,154
Lebanon
33,962
333
14,778
18,851
Serbia
33,312
746
31,536
1,030
Libyan Arab Jamahiriya
31,290
491
17,508
13,291
El Salvador
28,415
826
22,643
4,946
Australia
27,016
870
24,571
1,575
Bosnia
26,797
820
19,746
6,231
Denmark
26,213
648
19,350
6,215
S. Korea
23,516
399
21,166
1,951
Hungary
23,077
730
5,099
17,248
Cameroon
20,712
418
19,440
854
Bulgaria
19,828
789
14,132
4,907
Côte d'Ivoire
19,556
120
19,065
371
Macedonia
17,343
721
14,422
2,200
Greece
16,913
369
9,989
6,555
Madagascar
16,257
229
14,922
1,106
Croatia
16,007
269
14,405
1,333
Senegal
14,869
306
12,028
2,535
Zambia
14,515
332
13,643
540
Tunisia
14,392
191
5,032
9,169
Sudan
13,592
836
6,764
5,992
Norway
13,545
270
11,190
2,085
Albania
13,045
373
7,309
5,363
Namibia
10,835
119
8,569
2,147
Malaysia
10,769
133
9,785
851
DRC
10,593
271
10,093
229
Guinea
10,478
65
9,816
597
Maldives
10,014
34
8,673
1,307
Montenegro
9,962
155
6,177
3,630
French Guiana
9,831
65
9,472
294
Finland
9,577
343
7,850
1,384
Tajikistan
9,562
74
8,341
1,147
Myanmar
9,112
174
2,381
6,557
Gabon
8,728
54
7,934
740
Haiti
8,684
227
6,551
1,906
Slovakia
8,600
44
4,098
4,458
Luxembourg
8,233
124
6,976
1,133
Zimbabwe
7,787
227
6,057
1,503
Mozambique
7,589
53
4,649
2,887
Mauritania
7,457
161
7,070
226
Uganda
7,218
71
3,611
3,536
Jordan
7,211
39
4,035
3,137
Malawi
5,764
179
4,178
1,407
Jamaica
5,723
80
1,496
4,147
Cabo Verde
5,628
55
4,982
591
Djibouti
5,409
61
5,340
8
Swaziland
5,399
108
4,767
524
Cuba
5,350
118
4,658
574
Slovenia
5,191
146
3,457
1,588
Nicaragua
5,073
149
2,913
2,011
Hong Kong
5,060
105
4,777
178
Equatorial Guinea
5,018
83
4,530
405
Congo
5,005
89
3,887
1,029
Georgia
4,960
28
1,819
3,113
Suriname
4,817
102
4,596
119
Central African Republic
4,806
62
1,840
2,904
Rwanda
4,798
29
3,080
1,689
Angola
4,590
167
1,554
2,869
Guadeloupe
4,487
42
2,199
2,246
Lithuania
4,295
89
2,319
1,887
Trinidad and Tobago
4,277
70
2,122
2,085
Syrian Arab Republic
4,001
185
1,028
2,788
Aruba
3,799
25
2,753
1,021
Bahamas
3,790
89
1,999
1,702
Réunion
3,685
11
2,819
855
Gambia
3,555
110
2,034
1,411
Mayotte
3,541
40
2,964
537
Thailand
3,522
59
3,362
101
Somalia
3,465
98
2,877
490
Sri Lanka
3,345
13
3,186
146
Estonia
3,165
64
2,499
602
Mali
3,064
130
2,402
532
Malta
2,958
31
2,304
623
Botswana
2,921
16
701
2,204
Guyana
2,709
73
1,490
1,146
South Sudan
2,676
49
1,290
1,337
Iceland
2,561
10
2,151
400
Benin
2,325
40
1,960
325
Guinea-Bissau
2,324
39
1,549
736
Sierra Leone
2,199
72
1,678
449
Yemen
2,029
587
1,255
187
Uruguay
1,967
47
1,710
210
Burkina Faso
1,962
56
1,263
643
Andorra
1,836
53
1,263
520
New Zealand
1,831
25
1,745
61
Belize
1,808
23
1,134
651
Togo
1,722
44
1,312
366
Cyprus
1,671
22
1,369
280
Latvia
1,654
36
1,304
314
French Polynesia
1,579
6
1,335
238
Lesotho
1,558
35
797
726
Liberia
1,338
82
1,221
35
Martinique
1,290
20
98
1,172
Niger
1,194
69
1,107
18
Chad
1,175
83
1,004
88
Vietnam
1,069
35
999
35
Sao Tome and Principe
911
15
881
15
San Marino
727
42
676
9
Diamond Princess
712
13
651
48
Turks and Caicos Islands
680
5
617
58
Channel Islands
656
48
600
8
Sint Maarten
627
22
532
73
Papua New Guinea
532
7
516
9
Taiwan
510
7
480
23
Tanzania
509
21
183
305
Burundi
483
1
462
20
Comoros
474
7
453
14
Faroe Islands
458
0
417
41
Gibraltar
372
0
335
37
Eritrea
369
0
330
39
Saint Martin
367
8
273
86
Mauritius
367
10
343
14
Isle of Man
340
24
314
2
Curaçao
329
1
124
204
Mongolia
313
0
303
10
Cambodia
275
0
274
1
Bhutan
263
0
199
64
Cayman Islands
210
1
207
2
Monaco
208
2
167
39
Barbados
190
7
175
8
Bermuda
181
9
167
5
Brunei
146
3
142
1
Seychelles
143
0
140
3
Liechtenstein
117
1
110
6
Antigua and Barbuda
98
3
92
3
Caribbean Netherlands
85
1
21
63
British Virgin Islands
71
1
62
8
Saint Vincent and the Grenadines
64
0
64
0
Macao
46
0
46
0
St. Barth
45
0
25
20
Fiji
32
2
28
2
Saint Lucia
27
0
27
0
Timor-Leste
27
0
27
0
New Caledonia
27
0
26
1
Dominica
24
0
18
6
Grenada
24
0
24
0
Lao People's Democratic Republic
23
0
22
1
Saint Kitts and Nevis
19
0
17
2
Saint Pierre Miquelon
16
0
6
10
Greenland
14
0
14
0
Falkland Islands (Malvinas)
13
0
13
0
Montserrat
13
1
12
0
Holy See (Vatican City State)
12
0
12
0
Western Sahara
10
1
8
1
MS Zaandam
9
2
0
7
Anguilla
3
0
3
0
Updated on September 26, 2020 1:36 pm

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