Tuesday, January 26, 2021
Home Corona China’s Enters Phase-3 Trial Of COVID-19 Vaccine

China’s Enters Phase-3 Trial Of COVID-19 Vaccine

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Seoul Jun 25: China reached an important new level of vaccine development with the start of phase three clinical trial of an inactivated vaccine candidate against COVID-19 in the United Arab Emirates.

It is the first vaccine of its kind to reach a late-stage, mass-scale human trial, according to China National Biotec Group, China Daily reported on Thursday.

The Institute of Microbiology of the Chinese Academy of Sciences said in a statement that Chinese authorities approved the phase one trial of the nation’s first recombinant protein vaccine against COVID-19.

The recombinant protein vaccine is the nation’s third type of vaccine, after an adenovirus vector vaccine and the inactivated vaccine, to enter clinical trials in China, the statement said.

The Wuhan and Beijing units of the CNBG each developed an inactivated vaccine candidate, and one or the other of these vaccine candidates were tested on a group of 2,240 people during phase one and two clinical trials, the CNBG said.

The Wuhan Covid19-Vaccine was found to be effective and safe, with no serious adverse effects, according to trial results published on June 16.

Various dosages and timings were tried. Those who received two doses at an interval of 28 days, all in the 18 to 59 age group, tested positive for neutralizing antibodies against the novel coronavirus.

The Beijing vaccine’s test results will be published on June 28, the CNBG said. The UAE Ministry of Health and Prevention has approved the phase three trials, though it is unclear which Covid19-Vaccine will be used.

As for the recombinant protein vaccine, the Institute of Microbiology said in the statement that it has been shown to be safe and effective in animal tests and is easy to mass-produce.

China’s recombinant protein vaccine candidate has been jointly developed by the Institute of Microbiology and Anhui Zhifei Longcom Biopharmaceutical. The United States, Israel, Japan, Argentina, Thailand, and other countries are working on similar recombinant vaccines, according to the World Health Organization.

Unlike an inactivated vaccine, which uses a whole dead targeted virus, and a vector vaccine, which uses a chemically weakened second virus as a carrier, a recombinant protein vaccine uses only part of the targeted virus to trigger a protective immune response.

This type of vaccine is known to provide very strong protection and is safe even for people who are immuno-compromised, the United States’ National Institutes of Health said. Common recombinant vaccines include those against hepatitis B, influenza, whooping cough, and human papillomavirus or HPV.

Some recombinant vaccines, however, require booster shots for ongoing protection. They also need added substances to enhance the immune response, the NIH said.

The novel coronavirus uses its spike protein to bind to ACE2 receptors on human cells and subsequently infect them. Therefore, scientists have chosen to focus on the spike protein as one of the major targets for vaccines and therapeutics.

The Institute of Microbiology said its recombinant protein vaccine has been tested on mice and rhesus monkeys and shown to produce highly potent virus-neutralizing antibodies.

It also said the viral load in the test animals decreased noticeably, reducing the virus damage to lung tissues.

Moreover, the process used to manufacture the Covid19-Vaccine can be upgraded to an industrial scale, resulting in high production output, low cost, and relatively strong practicality.

However, the institute stressed that much work still has to be done in human trials before the Covid19-Vaccine could reach the market.

As of now, the WHO had recorded around 142 candidate vaccines in development around the globe, 13 of which have entered clinical trials. The AZD1222 vaccine candidate, created by researchers from the University of Oxford and biotech company AstraZeneca, entered concurrent phase two and three trials in the United Kingdom in late May.

In mid-June, US biotech company Moderna finalized its protocol for the phase three trial of its COVID-19 nucleic acid vaccine candidate mRNA-1273.

Chinese scientists and companies have tested six potential vaccines in clinical trials in China, including one vector, four inactivated, and one recombinant protein vaccine.

Two Chinese-vaccine developers, CanSino and Sinovac Biotech have previously announced they plan to conduct phase three clinical trials of their products and related research in Canada and Brazil, respectively.

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Total Cases

43,405,696

Total Deaths

1,159,835

Total Recovered

31,935,211

Country/Region
Confirmed cases
Deaths
Recovered
Active cases
USA
25,874,814
432,031
15,621,586
9,821,197
India
10,689,202
153,722
10,356,476
179,004
Brazil
8,881,853
217,806
7,709,602
954,445
Russia
3,756,931
70,482
3,174,561
511,888
UK
3,689,746
100,162
1,648,218
1,941,366
France
3,057,857
73,494
217,708
2,766,655
Spain
2,697,294
56,208
0
2,641,086
Italy
2,475,372
85,881
1,897,861
491,630
Turkey
2,442,350
25,344
2,322,511
94,495
Germany
2,158,594
53,837
1,844,000
260,757
Colombia
2,027,746
51,747
1,849,194
126,805
Argentina
1,874,801
47,034
1,666,527
161,240
Mexico
1,771,740
150,273
1,335,876
285,591
Poland
1,482,722
35,665
1,243,575
203,482
South Africa
1,417,537
41,117
1,241,421
134,999
Iran
1,385,706
57,560
1,177,367
150,779
Ukraine
1,197,107
22,057
965,835
209,215
Peru
1,102,795
39,887
1,017,544
45,364
Indonesia
1,012,350
28,468
820,356
163,526
Netherlands
956,867
13,665
0
943,202
Czechia
946,946
15,618
831,394
99,934
Canada
755,917
19,357
675,505
61,055
Romania
715,438
17,938
658,595
38,905
Chile
706,500
18,023
662,460
26,017
Belgium
694,858
20,814
48,187
625,857
Portugal
653,878
11,012
475,485
167,381
Iraq
615,380
13,010
584,752
17,618
Israel
610,760
4,498
529,834
76,428
Sweden
556,289
11,247
0
545,042
Pakistan
535,914
11,376
490,126
34,412
Bangladesh
532,916
8,055
477,426
47,435
Philippines
516,166
10,386
475,423
30,357
Switzerland
515,483
9,187
317,600
188,696
Morocco
466,626
8,172
443,472
14,982
Austria
407,140
7,515
384,926
14,699
Serbia
387,206
3,924
31,536
351,746
Japan
368,143
5,158
301,540
61,445
Saudi Arabia
366,807
6,359
358,340
2,108
Hungary
360,877
12,113
244,681
104,083
Jordan
322,241
4,248
310,005
7,988
Panama
312,158
5,098
261,291
45,769
UAE
285,147
805
259,194
25,148
Lebanon
282,249
2,374
168,142
111,733
Nepal
270,092
2,017
264,823
3,252
Georgia
254,822
3,096
244,446
7,280
Ecuador
242,146
14,668
204,071
23,407
Belarus
239,482
1,668
224,925
12,889
Slovakia
238,617
4,260
197,191
37,166
Croatia
229,502
4,882
222,110
2,510
Azerbaijan
229,358
3,100
221,116
5,142
Bulgaria
215,589
8,880
180,127
26,582
Dominican Republic
206,305
2,564
149,812
53,929
Bolivia
202,818
10,051
151,469
41,298
Tunisia
198,636
6,287
146,740
45,609
Denmark
195,948
2,030
182,420
11,498
Costa Rica
190,745
2,558
149,149
39,038
Malaysia
190,434
700
149,160
40,574
Ireland
188,923
2,977
23,364
162,582
Kazakhstan
179,720
2,403
161,758
15,559
Lithuania
177,934
2,688
121,907
53,339
Armenia
166,232
3,052
155,404
7,776
Egypt
162,486
9,012
127,001
26,473
Kuwait
162,282
957
155,303
6,022
Slovenia
159,812
3,406
138,272
18,134
Moldova
156,972
3,381
147,380
6,211
Palestine
156,393
1,803
146,279
8,311
Guatemala
154,430
5,469
139,113
9,848
Greece
153,226
5,692
141,612
5,922
Qatar
149,595
248
145,124
4,223
Honduras
141,984
3,462
60,477
78,045
Myanmar
138,368
3,082
122,781
12,505
Ethiopia
134,569
2,075
120,748
11,746
Oman
133,407
1,524
126,409
5,474
Paraguay
128,366
2,632
103,811
21,923
Venezuela
124,112
1,154
116,365
6,593
Nigeria
122,996
1,507
98,359
23,130
Bosnia
120,532
4,621
93,332
22,579
Libyan Arab Jamahiriya
115,299
1,789
94,287
19,223
Algeria
105,854
2,866
72,143
30,845
Bahrain
100,230
369
96,761
3,100
Kenya
100,193
1,750
83,625
14,818
Macedonia
91,161
2,812
79,621
8,728
China
89,197
4,636
82,676
1,885
Kyrgyzstan
84,068
1,402
80,182
2,484
Uzbekistan
78,471
621
76,912
938
S. Korea
75,875
1,371
64,793
9,711
Albania
73,691
1,332
44,880
27,479
Ghana
62,135
372
58,150
3,613
Latvia
61,924
1,126
49,035
11,763
Norway
61,463
550
53,299
7,614
Sri Lanka
59,536
287
51,046
8,203
Singapore
59,366
29
59,086
251
Montenegro
59,262
777
50,754
7,731
Afghanistan
54,854
2,389
47,459
5,006
El Salvador
53,479
1,583
47,073
4,823
Luxembourg
49,852
570
47,147
2,135
Zambia
47,622
672
40,362
6,588
Finland
43,120
655
31,000
11,465
Estonia
41,330
392
31,039
9,899
Uganda
39,261
318
14,051
24,892
Uruguay
38,041
390
30,143
7,508
Namibia
32,957
328
30,432
2,197
Mozambique
32,781
363
21,011
11,407
Zimbabwe
31,646
1,075
22,877
7,694
Cyprus
30,143
188
2,057
27,898
Cameroon
29,617
462
28,045
1,110
Australia
28,780
909
26,003
1,868
Côte d'Ivoire
27,096
146
25,000
1,950
Sudan
26,596
1,750
20,680
4,166
Senegal
25,127
592
20,870
3,665
Cuba
22,614
200
17,703
4,711
DRC
22,048
661
14,968
6,419
Botswana
20,658
124
16,794
3,740
Malawi
19,987
518
6,780
12,689
Angola
19,476
461
17,327
1,688
Madagascar
18,743
279
17,930
534
French Polynesia
17,912
129
4,842
12,941
Malta
16,999
255
14,104
2,640
Mauritania
16,421
417
15,305
699
French Guiana
15,702
76
9,995
5,631
Jamaica
15,153
339
11,911
2,903
Maldives
15,102
51
13,884
1,167
Thailand
14,646
75
10,892
3,679
Swaziland
14,622
493
9,394
4,735
Guinea
14,379
82
13,798
499
Syrian Arab Republic
13,697
890
7,121
5,686
Cabo Verde
13,557
127
12,751
679
Rwanda
13,311
177
8,681
4,453
Tajikistan
13,308
90
13,218
0
Belize
11,770
293
11,131
346
Haiti
11,286
243
8,997
2,046
Gabon
10,411
67
10,013
331
Hong Kong
10,223
172
9,101
950
Burkina Faso
10,103
117
8,388
1,598
Réunion
9,843
45
9,261
537
Andorra
9,596
97
8,724
775
Guadeloupe
8,980
154
2,242
6,584
Bahamas
8,133
175
6,720
1,238
Suriname
8,112
149
7,304
659
Lesotho
8,047
146
2,398
5,503
Mali
7,995
324
5,731
1,940
Congo
7,887
117
5,846
1,924
Mayotte
7,590
59
2,964
4,567
Trinidad and Tobago
7,490
134
7,033
323
Guyana
7,317
172
6,431
714
Aruba
6,742
57
6,294
391
Martinique
6,327
44
98
6,185
Nicaragua
6,204
168
4,225
1,811
Iceland
5,992
29
5,904
59
Djibouti
5,923
62
5,841
20
Equatorial Guinea
5,454
86
5,219
149
Central African Republic
4,980
63
4,885
32
Somalia
4,754
130
3,666
958
Togo
4,682
76
4,005
601
Curaçao
4,548
20
4,438
90
Niger
4,374
151
3,494
729
Gibraltar
4,024
69
3,401
554
Gambia
4,008
128
3,722
158
South Sudan
3,788
64
3,542
182
Benin
3,643
48
3,317
278
Channel Islands
3,499
79
3,227
193
Sierra Leone
3,194
77
2,232
885
Chad
3,182
116
2,260
806
San Marino
2,915
65
2,660
190
Guinea-Bissau
2,532
45
2,421
66
Liechtenstein
2,455
52
2,322
81
Comoros
2,350
76
1,424
850
New Zealand
2,290
25
2,200
65
Yemen
2,118
615
1,424
79
Eritrea
1,970
7
1,530
433
Liberia
1,932
84
1,733
115
Sint Maarten
1,758
27
1,598
133
Mongolia
1,656
2
1,211
443
Vietnam
1,551
35
1,430
86
Burundi
1,479
2
773
704
Barbados
1,401
10
649
742
Monaco
1,368
9
1,140
219
Turks and Caicos Islands
1,287
7
1,000
280
Sao Tome and Principe
1,210
17
1,005
188
Saint Martin
1,146
12
1,006
128
Seychelles
1,116
3
754
359
Saint Lucia
921
13
470
438
Taiwan
890
7
797
86
Bhutan
856
1
734
121
Papua New Guinea
850
9
812
29
Saint Vincent and the Grenadines
746
2
147
597
Diamond Princess
712
13
699
0
Bermuda
686
12
640
34
Faroe Islands
654
1
645
8
Mauritius
568
10
525
33
Tanzania
509
21
183
305
Cambodia
460
0
412
48
Isle of Man
432
25
364
43
Cayman Islands
383
2
346
35
Caribbean Netherlands
360
3
244
113
St. Barth
300
1
204
95
Antigua and Barbuda
201
6
170
25
Brunei
176
3
169
4
Grenada
148
1
135
12
British Virgin Islands
114
1
95
18
Dominica
113
0
105
8
Timor-Leste
67
0
50
17
Fiji
55
2
53
0
Macao
47
0
46
1
Lao People's Democratic Republic
44
0
41
3
New Caledonia
44
0
43
1
Falkland Islands (Malvinas)
35
0
29
6
Saint Kitts and Nevis
35
0
35
0
Greenland
30
0
30
0
Holy See (Vatican City State)
27
0
15
12
Saint Pierre Miquelon
23
0
16
7
Solomon Islands
17
0
10
7
Anguilla
16
0
15
1
Montserrat
13
1
12
0
Western Sahara
10
1
8
1
MS Zaandam
9
2
7
0
Wallis and Futuna
5
0
4
1
Marshall Islands
4
0
4
0
Samoa
2
0
2
0
Micronesia
1
0
0
1
Vanuatu
1
0
1
0
Updated on January 26, 2021 5:13 pm

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